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Poly(lactic-co-glycolic acid) electrospun fibrous meshes for the controlled release of retinoic acid

Paper ID Volume ID Publish Year Pages File Format Full-Text
2500 114 2010 11 PDF Available
Title
Poly(lactic-co-glycolic acid) electrospun fibrous meshes for the controlled release of retinoic acid
Abstract

Poly(lactic-co-glycolic acid) (PLGA) meshes loaded with retinoic acid (RA) were prepared by applying the electrospinning technique. The purpose of the present work was to combine the biological effects of RA and the advantages of electrospun meshes to enhancing the mass transfer features of controlled release systems and cell interaction with polymeric scaffolds. The processing conditions for the fabrication of three-dimensional meshes were optimized by studying their influence on mesh morphology. Tensile testing showed that RA loading influenced the meshes’ mechanical properties by increasing their strength and rigidity. Moreover, the drug release and degradation profiles of the electrospun systems were compared to analogous RA-loaded PLGA films prepared by solvent casting. The results of this study highlight that the electrospun meshes preserved their fibrous structure after 4 months under in vitro physiological conditions and showed a sustained controlled release of the loaded agent in comparison to that observed for cast films. The bioactivity of the loaded RA was investigated on murine preosteoblasts cells by evaluating its influence on cell proliferation and morphology.

Keywords
Electrospinning; Controlled release; Retinoic acid; Ultrafine polymeric fibers
First Page Preview
Poly(lactic-co-glycolic acid) electrospun fibrous meshes for the controlled release of retinoic acid
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 4, April 2010, Pages 1258–1268
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering