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Manipulation of process parameters to achieve different ternary phase microparticle configurations

Paper ID Volume ID Publish Year Pages File Format Full-Text
2509 114 2010 11 PDF Available
Title
Manipulation of process parameters to achieve different ternary phase microparticle configurations
Abstract

Ternary phase microparticles of poly(d,l-lactide-co-glycolide) (50:50), poly(l-lactide) and poly(caprolactone) were fabricated through a one-step solvent evaporation technique. The purpose of this study was to examine the effects of various process parameters on the final configuration (i.e. polymer distribution and dimensions) of these composite microparticles and, subsequently, propose their mechanism of formation. Particle morphologies and configurations were determined using scanning electron microscopy, polymer dissolution tests and Raman mapping. It was found that a starting polymer solution prepared below the cloud point and an increased oil to water ratio will facilitate polymer configurations close to thermodynamic equilibrium, which is dictated by the interfacial energies of the components. By varying the polymer mass ratio or adjusting the precipitation rate, through stirring speed and oil to water ratio, a wide range of microparticles with different core–shell dimensions and embedded particulate sizes can also be fabricated. At the same time, lowering the polymer solution concentration and increasing the stirring speed may result in smaller microparticles. Correlation of these process parameters with the final composite particle morphology was thus established. This understanding should allow the controlled fabrication of ternary phase composite microparticles through a single step solvent evaporation technique.

Keywords
Polylactic acid; Poly(lactide-co-glycolide); Poly(caprolactone); Double walled microparticles; Drug delivery
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 4, April 2010, Pages 1342–1352
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us