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β-Ga2O3:Cr3+ nanoparticle: A new platform with near infrared photoluminescence for drug targeting delivery and bio-imaging simultaneously

Paper ID Volume ID Publish Year Pages File Format Full-Text
252 20 2015 9 PDF Available
Title
β-Ga2O3:Cr3+ nanoparticle: A new platform with near infrared photoluminescence for drug targeting delivery and bio-imaging simultaneously
Abstract

Multifunctional nanoparticles which integrate the therapeutic agents and bio-imaging agents into one carrier are emerging as a promising therapeutic platform. Herein, GaOOH:Cr3+ was firstly synthesized using improved hydrothermal method (atmospheric pressure, 95 °C), and by manipulating the pH of the reaction medium, GaOOH:Cr3+ with different sizes (125.70 nm, 200.60 nm and 313.90 nm) were synthesized. Then β-Ga2O3:Cr3+ nanoparticles with porous structures were developed as a result of the calcination of GaOOH:Cr3+. The fabricated, porous β-Ga2O3:Cr3+ nanoparticles could effectively absorb doxorubicin hydrochloride (DOX) (loading rate: 8% approximately) and had near infrared photoluminescence with a 695 nm emission. Furthermore, β-Ga2O3:Cr3+ nanoparticles were coated with l-Cys modified hyaluronic acid (HA-Cys) by exploiting the electrostatic interaction and the cross-link effect of disulfide bond to improve the stability. The DOX loaded HA-Cys coated β-Ga2O3:Cr3+ nanoparticles (HA/β-Ga2O3:Cr3+/DOX) showed an oxidation–reduction sensitive drug release behavior. The HA-Cys coated β-Ga2O3:Cr3+ nanoparticles showed a low cytotoxicity on MCF-7 and Hela cell lines. The cellular uptake of HA/β-Ga2O3:Cr3+/DOX using the near infrared photoluminescence of β-Ga2O3:Cr3+ nanoparticles and the fluorescence of DOX demonstrated the HA/β-Ga2O3:Cr3+/DOX could internalize into tumor cells quickly, which was affected by the size and shape of β-Ga2O3:Cr3+nanoparticles.

Graphical abstractSynthesis of nanoparticles and cellular uptake: Three different sizes of β-Ga2O3:Cr3+ were synthesized and were used as drug carriers. After coating by l-Cys modified hyaluronic acid, they could internalize in cancer cell via CD44 receptor-mediated endocytosis, and near infrared fluorescence was showed under exciting light, which could be used for bio-imaging.Figure optionsDownload full-size imageDownload high-quality image (219 K)Download as PowerPoint slide

Keywords
β-Ga2O3:Cr3+; Nanoparticles; Bio-imaging; Drug carrier; Hyaluronic acid
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β-Ga2O3:Cr3+ nanoparticle: A new platform with near infrared photoluminescence for drug targeting delivery and bio-imaging simultaneously
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 22, August 2015, Pages 164–172
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us