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Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genes

Paper ID Volume ID Publish Year Pages File Format Full-Text
25338 43568 2006 14 PDF Available
Title
Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genes
Abstract

Fungal polyketides comprise a diverse group of secondary metabolites that play an important role for drug discovery, as pigments, and as mycotoxins. Their biosynthesis is governed by multidomain enzymes, so-called fungal type I polyketide synthases (PKS). Investigating the molecular basis of polyketide biosynthesis in fungi is of great importance for ecological and pharmacological reasons. In addition, cloning, functional analysis and expression of fungal PKS genes also set the basis for engineering the yet largely untapped biosynthetic potential.

Keywords
Fungi; Metabolic engineering; Natural products; Polyketides
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Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genes
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 124, Issue 4, 5 August 2006, Pages 690–703
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us