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High level expression of bioactive recombinant human growth hormone in the milk of a cloned transgenic cow

Paper ID Volume ID Publish Year Pages File Format Full-Text
25411 43572 2006 4 PDF Available
Title
High level expression of bioactive recombinant human growth hormone in the milk of a cloned transgenic cow
Abstract

Transgenic farm animals have been proposed as an alternative to current bioreactors for large scale production of biopharmaceuticals. However, the efficiency of both methods in the production of the same protein has not yet been established. Here we report the production of recombinant human growth hormone (hGH) in the milk of a cloned transgenic cow at levels of up to 5 g l−1. The hormone is identical to that currently produced by expression in E. coli. In addition, the hematological and somatometric parameters of the cloned transgenic cow are within the normal range for the breed and it is fertile and capable of producing normal offspring. These results demonstrate that transgenic cattle can be used as a cost-effective alternative for the production of this hormone.

Keywords
Recombinant hGH; Transgenic cloned cow; Animal biotechnology
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High level expression of bioactive recombinant human growth hormone in the milk of a cloned transgenic cow
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 124, Issue 2, 13 July 2006, Pages 469–472
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us