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Substrate and inhibitor specificity of class 1 and class 2 histone deacetylases

Paper ID Volume ID Publish Year Pages File Format Full-Text
25453 43574 2006 13 PDF Available
Title
Substrate and inhibitor specificity of class 1 and class 2 histone deacetylases
Abstract

Histone deacetylases (HDACs) are key enzymes in the transcriptional regulation of gene expression in eukaryotic cells. In recent years HDACs have attracted considerable attention as promising new targets in anticancer therapy. Currently, different histone deacetylase subtypes are divided into four groups denoted as classes 1–4. Here, we compare in more detail representatives of class 1 HDACs and FB188 HDAH as a close bacterial homologue of class 2 HDAC6, in regard of substrate and inhibitor specificity. Structure comparison is used to identify candidate regions responsible for observed specificity differences. Knowledge of these structural elements expedite studies on the biochemical role of different HDAC subtypes as well as the development of highly selective HDAC inhibitors as antitumor agents.

Keywords
Histone deacetylase; FB188 HDAH; Substrate specificity; Hydroxamate inhibitors; X-ray crystallographic structure; Cancer therapy
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Substrate and inhibitor specificity of class 1 and class 2 histone deacetylases
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 124, Issue 1, 25 June 2006, Pages 258–270
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us