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Developing and analyzing idealized models for molecular recognition

Paper ID Volume ID Publish Year Pages File Format Full-Text
25465 43575 2007 11 PDF Available
Title
Developing and analyzing idealized models for molecular recognition
Abstract

We study equilibrium aspects of molecular recognition of two biomolecules using idealized model systems and methods from statistical physics. Starting from the basic experimental findings we demonstrate exemplarily how an idealized coarse-grained model for the investigation of molecular recognition of two biomolecules can be developed. In addition we provide details regarding two model systems for the recognition of a flexible and a rigid biomolecule respectively, the latter taking into account conformational changes. We focus particularly on the interplay and influence of the correlations of the residue distributions of the biomolecules on the recognition process.

Keywords
Biophysics; Molecular recognition; Model reduction; Coarse-graining
First Page Preview
Developing and analyzing idealized models for molecular recognition
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 129, Issue 2, 30 April 2007, Pages 268–278
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering