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DNA-encoded chemical libraries

Paper ID Volume ID Publish Year Pages File Format Full-Text
25627 43585 2006 14 PDF Available
Title
DNA-encoded chemical libraries
Abstract

The discovery and development of novel drugs for the multitude of targets originating from functional genomic research is a challenging task. While antibodies can nowadays be raised against virtually any given target using phage-display methodologies, a similar “selection/amplification” approach for the facile discovery of low-molecular weight compounds capable of specific binding to protein targets of choice has so far been lacking. The development of DNA-encoded chemical libraries, combined with suitable selection and high-throughput sequencing strategies, holds promises to fill this gap. Here, we review the latest developments in the field of DNA-encoded chemical libraries, commenting on the challenges and opportunities for the different experimental strategies in this rapidly evolving research area, which may gain importance for the future drug discovery process.

Keywords
DMT, 4,4′-dimethoxytrityl group; Fmoc, 9-fluorenylmethyloxycarbonyl groupDrug discovery; Chemical libraries; DNA-encoding; Self-assembly; DNA-templated synthesis; Affinity-based selections
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DNA-encoded chemical libraries
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 126, Issue 4, 1 December 2006, Pages 568–581
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us