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Lipase-catalyzed synthesis of sorbitol–fatty acid esters at extremely high substrate concentrations

Paper ID Volume ID Publish Year Pages File Format Full-Text
25650 43588 2006 11 PDF Available
Title
Lipase-catalyzed synthesis of sorbitol–fatty acid esters at extremely high substrate concentrations
Abstract

Lipase-catalyzed synthesis of sorbitol–fatty acid esters was performed in eutectic media with extremely high substrate concentrations. Homogeneous eutectic melts of sorbitol and fatty acids of C6–C16 were prepared using an adjuvant mixture. Enhanced homogeneity of mixtures was confirmed by X-ray diffraction analysis. The substrate concentration was 3.63–6.67 M in the eutectic media, whereas in organic media the concentration was below 0.10 M. Esters were synthesized with an immobilized Candida antarctica lipase, and optimum conditions were analyzed. Compared to reactions in organic media, the initial reaction rate of ester synthesis and the overall productivity were significantly enhanced in eutectic media while the conversion yields were similar. Based on the kinetic analysis, highly viscous eutectic media were shown to influence the initial reaction rate and the apparent activation energy resulting in diffusion limitations.

Keywords
Eutectic media; High concentration; Enhanced homogeneity; Diffusion limitation
First Page Preview
Lipase-catalyzed synthesis of sorbitol–fatty acid esters at extremely high substrate concentrations
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 123, Issue 2, 17 May 2006, Pages 174–184
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering