fulltext.study @t Gmail

Chip calorimetry for the monitoring of whole cell biotransformation

Paper ID Volume ID Publish Year Pages File Format Full-Text
25699 43591 2006 12 PDF Available
Title
Chip calorimetry for the monitoring of whole cell biotransformation
Abstract

Efficient control of whole cell biotransformation requires quantitative real-time information about the thermodynamics and kinetics of growth and product formation. Heat production contains such information, but its technical application is restricted due to the high price of calorimetric devices, the difficulty of integrating them into existing bioprocesses and the slow response times of established microcalorimeters. A new generation of chip or nanocalorimeters may overcome these weaknesses. We thus tested a highly sensitive chip calorimeter for its applicability in biotechnological monitoring. It was used to monitor aerobic growth of suspended and immobilized Escherichia coli DH5α DSM 6897 and anaerobic growth of suspended Halomonas halodenitrificans CCM 286T. The chip data corresponded well with enthalpy balance calculations and measurements with a conventional calorimeter, indicating the applicability of the chip calorimeter for bioprocess control.

Keywords
Process control; Biosensor; Chip calorimeter; Biofilm
First Page Preview
Chip calorimetry for the monitoring of whole cell biotransformation
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 122, Issue 4, 20 April 2006, Pages 431–442
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us