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Three-dimensional analysis of shear wave propagation observed by in vivo magnetic resonance elastography of the brain ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
2575 116 2007 11 PDF Available
Title
Three-dimensional analysis of shear wave propagation observed by in vivo magnetic resonance elastography of the brain ☆
Abstract

Dynamic magnetic resonance elastography (MRE) is a non-invasive method for the quantitative determination of the mechanical properties of soft tissues in vivo. In MRE, shear waves are generated in the tissue and visualized using phase-sensitive MR imaging methods. The resulting two-dimensional (2-D) wave images can reveal in-plane elastic properties when possible geometrical biases of the wave patterns are taken into account. In this study, 3-D MRE experiments of in vivo human brain are analyzed to gain knowledge about the direction of wave propagation and to deduce in-plane elastic properties. The direction of wave propagation was determined using a new algorithm which identifies minimal wave velocities along rays from the surface into the brain. It was possible to quantify biases of the elastic parameters due to projections onto coronal, sagittal and transversal image planes in 2-D MRE. It was found that the in-plane shear modulus is increasingly overestimated when the image slice is displaced from narrow slabs of 2–5 cm through the center of the brain. The mean shear modulus of the brain was deduced from 4-D wave data with about 3.5 kPa. Using the proposed slice positions in 2-D MRE, this shear modulus can be reproduced with an acceptable error within a fraction of the full 3-D examination time.

Keywords
Magnetic resonance elastography; Brain; 3-D analysis; Direction of shear wave propagation; Shear modulus
First Page Preview
Three-dimensional analysis of shear wave propagation observed by in vivo magnetic resonance elastography of the brain ☆
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 3, Issue 1, January 2007, Pages 127–137
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering