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Hydrolase-catalyzed Michael addition of imidazoles to acrylic monomers in organic medium

Paper ID Volume ID Publish Year Pages File Format Full-Text
25761 43597 2006 8 PDF Available
Title
Hydrolase-catalyzed Michael addition of imidazoles to acrylic monomers in organic medium
Abstract

Hydrolase-catalyzed Michael addition of imidazole derivatives to acrylic monomers in organic medium was described. A serial of N-substituted imidazole derivatives were successfully synthesized in moderate yields by the catalysis of hydrolases in organic medium. Nine commercially available hydrolases from different sources were screened and all of them were found to be able to catalyze this type of addition reaction. The reaction yields depended on the solvent properties and the solvents with higher log P value supported this enzyme-catalyzed reaction to give higher conversion. Influence of the structure of the Michael acceptor and donor on the enzymatic Michael addition was also investigated. The acceptor with shorter alcohol chain afforded a higher yield. A more rapid conversion was observed when the donor had an electron-withdrawing group. This hydrolase-catalyzed Michael addition reaction has widened the applicability of biocatalysts in organic and bioorganic synthesis.

Keywords
Hydrolase; Michael addition; Imidazole; Acrylic; Organic medium
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Hydrolase-catalyzed Michael addition of imidazoles to acrylic monomers in organic medium
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Biotechnology - Volume 121, Issue 3, 10 February 2006, Pages 330–337
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
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