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Quinazoline copper(II) ensemble as turn-on fluorescence sensor for cysteine and chemodosimeter for NO

Paper ID Volume ID Publish Year Pages File Format Full-Text
25956 43924 2014 6 PDF Available
Title
Quinazoline copper(II) ensemble as turn-on fluorescence sensor for cysteine and chemodosimeter for NO
Abstract

•Quinazoline based fluorescence chemosensor is an ON–Off fluorescent sensor for Cu(II), the Cu(II) complex is an Off–ON sensor for Cys and an Off–ON chemodosimeter for NO.•QHYN displays simple method of synthesis and high stability.•TD-DFT calculations and cyclic voltammetric studies were performed for the recognition behaviour of QHYN upon addition of Cu2+.

A fluorescent quinazoline based chemosensor QHYN had been designed and synthesized. It exhibits high sensitivity and selectivity towards Cu2+ over other metal ions in DMSO:H2O (1:9, v/v) at pH = 7.4 [HEPES buffer] by fluorescence quenching. Addition of nitric oxide to a solution of this QHYN·Cu(II) restores the fluorescence. This is attributed to the reduction of the Cu(II) centre by nitric oxide to diamagnetic Cu(I). The fluorescence response of QHYN·Cu(II) to NO is direct and specific, which is a significant improvement over commercially available small molecule-based chemodosimeter probe that are capable of detecting NO. The QHYN·Cu(II) also acts as an efficient “off–on” fluorescent sensor for cysteine with high sensitivity.

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Keywords
Quinazoline; Copper(II); Cysteine; Nitric oxide; Off–On; TD-DFT
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Quinazoline copper(II) ensemble as turn-on fluorescence sensor for cysteine and chemodosimeter for NO
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 281, 1 May 2014, Pages 47–52
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us