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Cyclodextrins nanocavities effects on basic and acid fluorescence quenching of hydroxy-indoles

Paper ID Volume ID Publish Year Pages File Format Full-Text
26022 43930 2013 6 PDF Available
Title
Cyclodextrins nanocavities effects on basic and acid fluorescence quenching of hydroxy-indoles
Abstract

•The cyclodextrins effects on 5-hydroxy-indoles fluorescence emission in acid and alkaline quenching conditions were analyzed.•In both media a decrease in the values of KQ was measured in the presence of cyclodextrins.•A complete quenching inhibition produced by ionized cyclodextrins was determined for both substrates.•This study is particularly important for analytical determinations in such media.•The quenching protection by CDs and the quenching inhibition by ionized CDs is a general behavior of indole compounds.

The cyclodextrins effects on the serotonin (5HT) and 5-hydroxy-3-indolyl acetic acid (5HIA) fluorescence emission in acid and alkaline quenching conditions were analyzed. From Stern–Volmer plots, the quenching constants (KQ) were determined in the presence and absence of β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD). In both media a decrease in the values of KQ was observed in the presence of CDs, as compared with their absence. In acid media, the decrease was: 36–39% with βCD and 48–54% with HPβCD for 5HIA and 5HT, respectively. In basic media, with the neutral receptors, these values are 69–29% with βCD and 56–43% with HPβCD for 5HIA and 5HT, respectively. Moreover, a complete quenching inhibition produced by ionized cyclodextrins was determined for both substrates. The results showed a net protective effect due to the guest inclusion into the cyclodextrin nanocavity. This study is particularly important for analytical determinations in such media.

Keywords
Serotonin; 5-Hydroxy-3-indolyl acetic acid; Cyclodextrin nanocavity; Fluorescence quenching; Protective inhibition
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Cyclodextrins nanocavities effects on basic and acid fluorescence quenching of hydroxy-indoles
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 261, 1 June 2013, Pages 20–25
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us