fulltext.study @t Gmail

Tetrakis{2-[N-((3-morpholino)propyl)carbamate]oxyethyl} zinc(II) phthalocyanine and its water soluble derivatives: Synthesis, photophysical, photochemical and protein binding properties

Paper ID Volume ID Publish Year Pages File Format Full-Text
26088 43933 2016 10 PDF Available
Title
Tetrakis{2-[N-((3-morpholino)propyl)carbamate]oxyethyl} zinc(II) phthalocyanine and its water soluble derivatives: Synthesis, photophysical, photochemical and protein binding properties
Abstract

•Water soluble moieties of 2-[N-((3-morpholino)propyl)carbamate]oxyethyl zinc phthalocyanine.•Investigation of photophysical and photochemical properties of these novel phthalocyanines.•Highly singlet oxygen generating photosensitizers.•Bovine serum albumin (BSA) binding behavior of these novel phthalocyanines.

In this study, the novel water soluble derivatives of 2-[N-((3-morpholino)propyl)carbamate]oxyethyl substituted zinc(II) phthalocyanine (1) bearing different type of groups such as sulfobetaine (2), betaine (3), N-Oxide (4) and quaternized methyl (5) on the morpholine core were synthesized for the first time. All newly synthesized zinc(II) phthalocyanine derivatives were characterized by different spectroscopic techniques such as UV–vis, FT-IR, 1H NMR, mass and elemental analysis as well. They showed excellent solubility in aqueous media due to their zwitterionic and ionic characters which makes them promising candidates for treatment of cancer by photodynamic therapy (PDT). The photophysical and photochemical properties were investigated in DMSO for tetrakis{2-[N-((3-morpholino)propyl)carbamate]oxyethyl} substituted zinc(II) phthalocyanine (1) and in both DMSO and water + Triton X-100 solutions for its water soluble ionic derivatives (2-5). The binding behaviors of ionic zinc(II) phthalocyanines by bovine serum albumin (BSA) protein were investigated for determination of transportation ability of these phthalocyanines in the blood circulation.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideIn this study, the novel water soluble derivatives of 2-[N-((3-morpholino) propyl) carbamate] oxyethyl substituted zinc(II) phthalocyanine (1) bearing different type of groups such as sulfobetaine (2), betaine (3), N-Oxide (4) and quaternized methyl (5) on the morpholine core were synthesized for the first time. They showed excellent solubility in aqueous media due to their ionic and zwitterionic characters which makes them promising candidates for treatment of cancer by photodynamic therapy (PDT).

Keywords
Phthalocyanine; Ionic; Zwitterionic; Fluorescence; Singlet oxygen
First Page Preview
Tetrakis{2-[N-((3-morpholino)propyl)carbamate]oxyethyl} zinc(II) phthalocyanine and its water soluble derivatives: Synthesis, photophysical, photochemical and protein binding properties
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 325, 1 July 2016, Pages 125–134
Authors
, , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us