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Axially paraben substituted silicon(IV) phthalocyanines towards dental pathogen Streptococcus mutans: Synthesis, photophysical, photochemical and in vitro properties

Paper ID Volume ID Publish Year Pages File Format Full-Text
26196 43939 2015 10 PDF Available
Title
Axially paraben substituted silicon(IV) phthalocyanines towards dental pathogen Streptococcus mutans: Synthesis, photophysical, photochemical and in vitro properties
Abstract

•Synthesis and fully characterization of a series of silicon(IV) phthalocyanines as antimicrobial photosensitizers.•Investigation of absorption, fluorescence, singlet oxygen generation and photodegradation properties.•Time-resolved fluorescence studies.•Antibacterial photodynamic efficacy studies against pathogenic bacterium Streptococcus mutans.

A series of silicon(IV) phthalocyanines axially substituted with methylparaben, ethylparaben, propylparaben and butylparaben groups were synthesized and studied as photosensitizers for antimicrobial photodynamic therapy. The absorption, fluorescence, photodegradation and singlet oxygen generation properties of the synthesized Si(IV) phthalocyanines were studied. In vitro antibacterial photodynamic therapy was investigated against cariogenic pathogenic bacterium Streptococcus mutans. Axially propylparaben substituted Si(IV) phthalocyanine showed significant photodynamic efficacy (log 4) at concentration of 10 μM and mild irradiation (60 mW cm−2, 50 J cm−2, LED 637 nm). The low inactivation capacity was observed for the other studied Si(IV) phthalocyanines. The uptake and localization properties of axially propylparaben substituted Si(IV) phthalocyanine showed a sufficient level of accumulation in planktonic cultured bacterium and a complete penetration depth into the biomass of the 48-h bacterial biofilm.

Graphical abstractA series of silicon(IV) phthalocyanines axially substituted with paraben derivatives were synthesized and the antibacterial photodynamic efficacy of these compounds were evaluated against pathogenic bacterium Streptococcus mutans.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Silicon phthalocyanine; Parabens; Antimicrobial photodynamic therapy; Pathogenic bacteria; Streptococcus mutan
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Axially paraben substituted silicon(IV) phthalocyanines towards dental pathogen Streptococcus mutans: Synthesis, photophysical, photochemical and in vitro properties
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 306, 15 June 2015, Pages 31–40
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us