fulltext.study @t Gmail

Novel indotricarbocyanine dyes covalently bonded to polyethylene glycol for theranostics

Paper ID Volume ID Publish Year Pages File Format Full-Text
26286 43944 2016 6 PDF Available
Title
Novel indotricarbocyanine dyes covalently bonded to polyethylene glycol for theranostics
Abstract

•Water-soluble indotricarbocyanine dyes covalently bonded to polyethylene glycols are synthesized.•Synthesized dyes show high photodynamic activity and tumor specificity.•Phototherapeutic activity was observed on light exposure at a wavelengths of 668, 740 and 780 nm.•The necrotic area after local photoirradiation was observed to a depth of 2.5 cm.

The synthesis methods for the indotricarbocyanine dyes covalently bonded to polyethylene glycols with varying degrees of polymerization have been developed. New indotricarbocyanine was synthesized in one step using the Mukayama reagent in polyethylene glycol with cesium fluoride as a basic catalyst. In vivo investigation of the phototherapeutic dye activity has shown selective recognition of malignant tissues, where accumulation of the dye was 4–5 times higher than in normal tissues. The necrotic area after local photoirradiation at the effective energy fluence 180 J/cm2, λ = 780 nm was observed to a depth of 2.5 cm making the synthesized dyes very promising for further pharmaceutic research.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Indotricarbocyanine dyes; Photodynamic therapy; HeLa cells; Photo and dark cytotoxicity
First Page Preview
Novel indotricarbocyanine dyes covalently bonded to polyethylene glycol for theranostics
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 316, 1 February 2016, Pages 31–36
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us