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Photophysics of an octasubstituted zinc(II) phthalocyanine incorporated into solid polymeric magnetic and non-magnetic PLGA–PVA nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
26288 43944 2016 8 PDF Available
Title
Photophysics of an octasubstituted zinc(II) phthalocyanine incorporated into solid polymeric magnetic and non-magnetic PLGA–PVA nanoparticles
Abstract

•Photosensitizer S1 was encapsulated into a biodegradable PLGA–PVA nanoparticles.•The nanoparticles were stabilized by PVA.•Incorporation of magnetite nanoparticles maintained singlet oxygen generation of S1.•An increase of singlet oxygen generation was obtained due to the heavy-atom effect.

2,3,9,10,16,17,23,24-octakis[(N,N-dimethylaminoethylsulfanyl)]phthalocyaninatozinc (II) (S1) was used as a lipophilic photosensitizer to be encapsulated into biodegradable poly(d,l lactide-co-glycolide)-polyvinyl alcohol nanoparticles. The synthesis, size, and spectroscopic, photophysical, and magnetic properties of nanoparticles, were analyzed. A greater number of sonication cycles afforded smaller nanoparticles. The stabilization by means of polyvinyl alcohol of all the nanoparticles synthesized provided a negative charge to the systems in a wide pH range. The thermograms obtained by differential scanning calorimetry showed that the nanoparticles were stabilized by polyvinyl alcohol. The incorporation of magnetite nanoparticles was verified by FT-IR, magnetization measurements by means of hysteresis curves and potential Z. S1 retained its efficiency in generating singlet oxygen. The incorporation of magnetite into the nanoparticles showed an increase in singlet oxygen quantum yields due to the heavy atom effect.

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Keywords
Phthalocyanines; Solid nanoparticles; Poly(d,l lactide-co-glycolide)-polyvinyl alcohol; Magnetite; Singlet oxygen
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Photophysics of an octasubstituted zinc(II) phthalocyanine incorporated into solid polymeric magnetic and non-magnetic PLGA–PVA nanoparticles
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 316, 1 February 2016, Pages 44–51
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us