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The different kinetic behavior of two potential photosensitizers for PDT

Paper ID Volume ID Publish Year Pages File Format Full-Text
26391 43950 2015 6 PDF Available
Title
The different kinetic behavior of two potential photosensitizers for PDT
Abstract

•The kinetic interaction between BSA and two potential PDT dyes was studied by stopped-flow.•The two dyes chosen were protoporphyrin IX (PPIX) and a squaraine dye (SQ1).•Thermodynamic and kinetic binding constants were evaluated for both interactions.•The kinetic of the interaction of the two dyes is very different.•Protoporphyrin IX showed a slow kinetic while SQ has a very fast kinetic interaction.

Photodynamic therapy (PDT) efficiency is affected by the nature of the binding between the photosensitizer and serum albumin. The kinetic interaction between two potential PDT dyes with bovine serum albumin was studied providing not only the rate constants but also demonstrating that the kinetic of the interaction of the two dyes is very different.

Keywords
PDT, photodynamic therapy; PS, photosensitizers; ROS, reactive oxygen radicals; BSA, bovine serum albumin; PPIX, protoporphyrin IX; SQ, squaraine dyePhotodynamic therapy; Fluorescence kinetics; Bovine serum albumin; Squaraine; Protoporphyrin
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 299, 15 February 2015, Pages 38–43
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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