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Synthesis, photochemical, bovine serum albumin and DNA binding properties of tetrasubstituted zinc phthalocyanines and their water soluble derivatives

Paper ID Volume ID Publish Year Pages File Format Full-Text
26405 43950 2015 14 PDF Available
Title
Synthesis, photochemical, bovine serum albumin and DNA binding properties of tetrasubstituted zinc phthalocyanines and their water soluble derivatives
Abstract

•Synthesis of water soluble zinc phthalocyanines.•Photophysical and photochemical properties for phthalocyanines.•Photodynamic therapy studies.•The bovine serum albumin and DNA binding behavior of phthalocyanines.

Tetra-substituted zinc (II) phthalocyanines (2a, 3a, 5a and 6a) were synthesized by cyclotetramerization of phthalonitrile derivatives (2, 3, 5 and 6). These zinc phthalocyanines (2a, 3a, 5a and 6a) were converted into their water-soluble quaternized derivatives (2b, 3b, 5b and 6b) by reaction with methyl iodide. The photophysical (fluorescence quantum yields and lifetimes) and photochemical (singlet oxygen and photodegradation quantum yields) properties of these novel compounds were investigated in dimethylsulfoxide for both non-ionic and quaternized ionic complexes and in phosphate buffer saline (PBS) for only quaternized ionic complexes. The effect of the two type substituents with different positions on the photophysical and photochemical properties of these phthalocyanines were compared in this study.

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Keywords
Phthalocyanine; Water soluble; Zinc; Quaternization; Photodynamic therapy; Photosensitizer
First Page Preview
Synthesis, photochemical, bovine serum albumin and DNA binding properties of tetrasubstituted zinc phthalocyanines and their water soluble derivatives
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 299, 15 February 2015, Pages 138–151
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering