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Bactericidal effect through non-uptake pathway with photofunctional silicon polymer that generates reactive oxygen species

Paper ID Volume ID Publish Year Pages File Format Full-Text
26434 43952 2016 7 PDF Available
Title
Bactericidal effect through non-uptake pathway with photofunctional silicon polymer that generates reactive oxygen species
Abstract

•The reactive oxygen species generating silicon polymer was successfully fabricated by simple solvent swell–encapsulation–shrink method.•Singlet oxygen generation from the photofunctional silicon polymer was directly confirmed with time and wavelength resolved singlet oxygen phosphorescence spectroscopy.•The photofunctional silicon polymer showed bactericidal effect on Gram-negative, Gram-positive, and fungi under mild experiment condition.•The photofunctional silicon film was applied for decomposition of the formed biofilm and the suppression of the biofilm formation.

We report bactericidal effect of photosensitizer (H2TPP: 5,10,15,20-tetraphenyl-21H,23H-porphyrin) through non-uptake pathway and efficacy of the photofunctional silicon polymer to the decomposition of the formed biofilm and the suppression of the biofilm formation. The photofunctional silicon polymer (PSP), which is the silicon polymer embedded with a photosensitizer, is fabricated by a simple solvent swell-encapsulation-shrink method. Reactive oxygen generation from PSP was confirmed by using the decomposition reaction of 1,3-diphnyl-isobenzofuran (DPBF). Also, singlet oxygen generation which is one of the reactive oxygen species (ROS) from PSP is directly confirmed with time and wavelength resolved singlet oxygen phosphorescence spectroscopy. For the influence study of ROS under the non-uptake condition of photosensitizer (PS to bacteria), photodynamic inactivation (PDI) effect of PSP is evaluated for Gram-positive, Gram-negative bacteria, and fungi. Those microorganisms were inactivated by PSP within 1 h under the given power of laser light (63.7 mW/cm2). Among the bacteria, especially, Staphylococcus aureus as the Gram-positive bacteria were completely disinfected under the given experimental condition. Furthermore, PSP successfully demonstrates the decomposition of the formed biofilm and the suppression of the biofilm formation with green light emitting diode (GLED, 3.5 mW/cm2, λmax = 517 nm, FWHM = 37 nm), which shows the practical application possibility of bactericidal material.

Keywords
Reactive oxygen species; Bactericidal effect; Photofunctional polymer; Non-uptake
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 315, 15 January 2016, Pages 52–58
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us