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Effects of pH on aggregation and photodynamic activities of cationic zinc phthalocyanines substituted with amides

Paper ID Volume ID Publish Year Pages File Format Full-Text
26537 43961 2014 12 PDF Available
Title
Effects of pH on aggregation and photodynamic activities of cationic zinc phthalocyanines substituted with amides
Abstract

•Two cationic phthalocyanines substituted with amides were synthesized.•Base can promote a shift in the amide/imidohydrine balance toward imidohydrine.•Base additive can greatly reduce aggregation of cationic phthalocyanine.•Base additive improves photodynamic activities of cationic phthalocyanine.•Base induced tautomeric transformation generate low aggregated phthalocyanine.

This work reports on the effects of pH (especially base addition) on the properties of two cationic phthalocyanines substituted with amide groups. The absorption spectra, photo-stability, singlet oxygen generation ability and photodegradation of CT DNA of the two cationic phthalocyanines in different pH were studied and compared. Results indicated that the base additive can promote a shift in the amide/imidohydrine balance toward imidohydrine, which resulted in the reduction of aggregate and enhancement of photodynamic activities. This base induced tautomeric transformation could be a novel way to generate low aggregated and high photodynamic efficiency cationic Pcs.

Graphical abstractThe base addition promote a shift in the amide/imidohydrine balance toward imidohydrine of a cationic phthalocyanines substituted with amides, thus, greatly reduce its aggregation degree in water.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Cationic phthalocyanines; pH; Aggregate; Photodynamic activity; Amide; Tautomeric transformation
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Effects of pH on aggregation and photodynamic activities of cationic zinc phthalocyanines substituted with amides
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 288, 15 August 2014, Pages 1–12
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us