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Unsymmetric indolylmaleimides: Synthesis, photophysical properties and amyloid detection

Paper ID Volume ID Publish Year Pages File Format Full-Text
26563 43963 2014 8 PDF Available
Title
Unsymmetric indolylmaleimides: Synthesis, photophysical properties and amyloid detection
Abstract

•Synthesis of various unsymmetric indolylmaleimides.•Unsymmetric indolylmaleimides having large Stokes shifts and different fluorescence emissions.•Unsymmetric indolylmaleimide detecting amyloid fibrils in senile systemic amyloidosis.

Various unsymmetric indolylmaleimides were synthesized. Their photophysical properties and affinities for amyloid fibrils were evaluated. Some unsymmetric indolylmaleimides have large Stokes shifts of more than 120 nm, fluorescence emission maxima wavelengths of more than 550 nm and different emissions under UV irradiation at 365 nm. From the results of histopathologic methods using stains, 3-(1H-indol-3-yl)-1-methyl-4-phenyl-1H-pyrrole-2,5-dione has high selectivity for amyloid fibrils in senile systemic amyloidosis.

Graphical abstractSome unsymmetric indolylmaleimides have large Stokes shifts of more than 120 nm, fluorescence emission maxima wavelengths of more than 550 nm and different emissions under UV irradiation at 365 nm. 3-(1H-indol-3-yl)-1-methyl-4-phenyl-1H-pyrrole-2,5-dione detects amyloid fibrils in senile systemic amyloidosis.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Fluorescence; Indolylmaleimide; π-Conjugation; Amyloid
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 289, 1 September 2014, Pages 39–46
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
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