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Arylstyrylimidazo[1,2-a]pyridine-based donor–acceptor acidochromic fluorophores: Synthesis, photophysical, thermal and biological properties

Paper ID Volume ID Publish Year Pages File Format Full-Text
26592 43965 2015 9 PDF Available
Title
Arylstyrylimidazo[1,2-a]pyridine-based donor–acceptor acidochromic fluorophores: Synthesis, photophysical, thermal and biological properties
Abstract

•A series of new fluorescent arylstyrylimidazo[1,2-a]pyridines was synthesized and fully characterized.•The absorption and emission properties of the compounds change drastically upon acidification.•The compounds show good thermal stability for practical applications.•They show DNA cleavage activity.

A series of new fluorescent arylstyrylimidazo[1,2-a]pyridines was synthesized and fully characterized. It is observed that the E isomers are stable in the solid state and in solutions. The absorption and emission properties of the compounds changed drastically upon acidification. The compounds showed good thermal stability for practical applications. In addition, antimicrobial, antioxidant, and DNA-cleavage activity of the compounds were examined. The results indicate that the compounds did not show any antimicrobial and antioxidant activity. However, they caused decreased mobility of form I DNA and also showed DNA cleavage activity.

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Keywords
Styryl dyes; Heterocycles; Imidazo[1,2-a]pyridines; pH Sensitive dyes; Fluorescent probes; DNA Cleavage activity
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Arylstyrylimidazo[1,2-a]pyridine-based donor–acceptor acidochromic fluorophores: Synthesis, photophysical, thermal and biological properties
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 310, 1 September 2015, Pages 113–121
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Don't Miss Today's Special Offer
Price was $35.95
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Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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