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Synthesis of two-photon active cinnamoyl coumarins for high-contrast imaging of cancer cells and their photophysical characterization

Paper ID Volume ID Publish Year Pages File Format Full-Text
26618 43967 2014 7 PDF Available
Title
Synthesis of two-photon active cinnamoyl coumarins for high-contrast imaging of cancer cells and their photophysical characterization
Abstract

•Two-photon (TP) active 4-dimethylaminocinnamoyl coumarins were synthesized.•Strong TPF was observed for each of the compounds.•These coumarins exhibited considerable Stokes shifts and moderate fluorescence quantum efficiencies.•These coumarins have the potential to be used in the development of a biological imaging probe.

A series of two-photon (TP) active 4-dimethylaminocinnamoyl coumarins were synthesized. These compounds exhibit red shift in absorption and considerable Stokes shift in emission spectra in comparison to the parent coumarin. Large TP absorption cross-sections were measured for all the coumarins in dilute solutions. A correlation between the chemical structure and TP characteristics was established. TP confocal microscopy revealed that these coumarin derivatives can be internalized by cancer cells rendering them a potential candidate as a label in TP confocal imaging.

Graphical abstractA series of two-photon (TP) active 4-dimethylaminocinnamoyl coumarins were synthesized that exhibit considerable Stokes shift in emission and can be internalized by cancer cells rendering them a potential candidate as a label in TP confocal imaging.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Two-photon active; 4-Dimethylaminocinnamoyl coumarins; Stokes shift; Label
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Synthesis of two-photon active cinnamoyl coumarins for high-contrast imaging of cancer cells and their photophysical characterization
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 280, 15 April 2014, Pages 39–45
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
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