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Synthesis and characterization of daunorubicin modified ZnO/PVP nanorods and its photodynamic action

Paper ID Volume ID Publish Year Pages File Format Full-Text
26649 43969 2013 9 PDF Available
Title
Synthesis and characterization of daunorubicin modified ZnO/PVP nanorods and its photodynamic action
Abstract

Nanomaterials have widely been used in the field of biological and biomedicine, such as tissue imaging, diagnosis and cancer therapy. The aim of this study is to investigate cytotoxicity and photodynamic effect of combined application of polyvinyl pyrrolidone (PVP) modified ZnO nanorods with anticancer drug daunorubicin (DNR) in photodynamic therapy (PDT). Daunorubicin (DNR) has a broad spectrum of anticancer activity, but it is limited in clinical application due to its serious side effects. In DNR-ZnO/PVP nanocomposites, ZnO/PVP nanorods act as drug carrier of DNR in drug delivery system (DNR-ZnO/PVP nanocomposites). This drug delivery system induced remarkable improvement in anticancer activity, as demonstrated by MTT assay using 3-(4,5-dimethylthiazol-2yl)-2,5 diphenyl tetrazolium bromide (MTT reagent). This has been also demonstrated by antibacterial activity and DNA cleavage study. The findings suggest that DNR delivery strategy is a promising approach to cancer therapy.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► ZnO/PVP nano modified with DNR were synthesized. ► DNR sensitized on ZnO/PVP nanocomposites were characterized. ► That DNR-ZnO/PVP nanocomposite generates 1O2 and inactivate the bacteria cell. ► It was found that photoinduced cleavage of DNA and HeLa cells using DNR-ZnO/PVP.

Keywords
ZnO nano; Surface modification; Daunorubicin; Singlet oxygen; Photoinactivation
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Synthesis and characterization of daunorubicin modified ZnO/PVP nanorods and its photodynamic action
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 252, 15 January 2013, Pages 107–115
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us