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Vitreous SiO2–CaO coatings on Ti6Al4V alloys: Reactivity in simulated body fluid versus osteoblast cell culture

Paper ID Volume ID Publish Year Pages File Format Full-Text
2665 122 2006 11 PDF Available
Title
Vitreous SiO2–CaO coatings on Ti6Al4V alloys: Reactivity in simulated body fluid versus osteoblast cell culture
Abstract

Vitreous coatings of the SiO2–CaO system have been prepared on Ti6Al4V substrates by the sol–gel method. The textural parameters (porosity and roughness) and thickness of the films obtained increase when the concentration of the precursor solutions is raised. In vitro studies of these coatings have been performed using two approaches: soaking in simulated body fluid, and by growing osteoblasts on these materials. The results of both studies show differences in terms of chemical reactivity. While in simulated body fluid the coatings were dissolved without forming a bioactive surface, when osteoblast-like cells grew on the coatings they were more stable. Furthermore, cell culture assays show biocompatible behavior of these coatings making them of potential interest for clinical applications. The effect of the textural parameters of the obtained coatings on the cell functions (attachment, spreading, proliferation and differentiation) has also been studied. The results show an increase in these cell parameters as the roughness and porosity of the coatings increase.

Keywords
SiO2–CaO coatings; In vitro assays; Biocompatibility assays; Roughness; Porosity
First Page Preview
Vitreous SiO2–CaO coatings on Ti6Al4V alloys: Reactivity in simulated body fluid versus osteoblast cell culture
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 2, Issue 4, July 2006, Pages 445–455
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering