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Mechanistic analysis of the fluorescence quenching of dodecyloxo(methoxo)tetraphenylporphyrinatoantimony by 9,10-dimethylanthracene in an artificial membrane constructed by a phospholipid liposome

Paper ID Volume ID Publish Year Pages File Format Full-Text
26749 43974 2012 6 PDF Available
Title
Mechanistic analysis of the fluorescence quenching of dodecyloxo(methoxo)tetraphenylporphyrinatoantimony by 9,10-dimethylanthracene in an artificial membrane constructed by a phospholipid liposome
Abstract

As a model for photodynamic therapy, photosensitization with dodecyloxo(methoxo)tetraphenylporphyrinatoantimony bromide was investigated in a phospholipid liposome (LP) constructed with 1,2-diparmitoyl-sn-glycerol 3-phosphocholine. The adsorption isotherms of the sensitizer into the LP showed Langmuir-type adsorption with binding constants in the order of 106 M−1. The sensitizer was bound to the LP by hydrophobic interactions with the dodecyloxo ligand and the core of the LP membrane. The photosensitized oxygenation reaction of 9,10-dimethylanthracene (DMA) with the sensitizer in the LP occurred efficiently at 0.73 of the limiting quantum yield. Fluorescence quenching and kinetic analysis suggested that the reaction proceeded through photoinduced electron transfer from DMA to the excited singlet state of the sensitizer.

► We construct a model system of photodynamic therapy with phospholipid liposome (LP). ► The LP could bind efficiently water-soluble Sb-porphyrin complexes (1). ► 1 could sensitize the oxidation of 9,10-dimethylanthracene (DMA) in the LP. ► The oxidation occurred through photoinduced electron transfer from DMA to 1.

Keywords
Photosensitized oxygenation; Fluorescence quenching; Liposome; Adsorption; Porphyrin; Photodynamic therapy
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Mechanistic analysis of the fluorescence quenching of dodecyloxo(methoxo)tetraphenylporphyrinatoantimony by 9,10-dimethylanthracene in an artificial membrane constructed by a phospholipid liposome
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 249, 1 December 2012, Pages 47–52
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us