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Kinetic modeling of substrate and product inhibition for 2,3-butanediol production by Klebsiella oxytoca

Paper ID Volume ID Publish Year Pages File Format Full-Text
2678 126 2016 7 PDF Available
Title
Kinetic modeling of substrate and product inhibition for 2,3-butanediol production by Klebsiella oxytoca
Abstract

•Kinetic models were proposed to describe the production of 2,3-BD by K. oxytoca.•The models have well elucidated the fermentative characteristics for 2,3-BD production.•The models provide information to improve the performance of 2,3-BD production.

There has been a growing interest in the fermentative production of 2,3-butanediol (2,3-BD) because of its wide applications in the chemical, food, pharmaceutical, and fuel industries. In this study, we set up kinetic models to predict the behavior of Klebsiella oxytoca ΔldhA mutant in the batch fermentation of 2,3-BD. Modified Monod model, Luedeking-Piret model, and carbon mass balance were employed to describe the effects of substrate and end-products on cell growth, 2,3-BD production, and substrate consumption, respectively. All the parameters in the models were estimated by minimizing mean-squared errors between the model predictions and experimental data. The model predictions were in good agreement with the fermentation data. In particular, the models accurately described the inhibitory effects of by-products on the growth of K. oxytoca ΔldhA mutant as well as the production of 2,3-BD. Although the models cannot describe the complex metabolic phenomena, this paper may provide useful information for design and optimization of 2,3-BD fermentation process.

Keywords
Klebsiella oxytoca; 2,3-Butanediol; Batch fermentation; Kinetic models; Inhibition
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Kinetic modeling of substrate and product inhibition for 2,3-butanediol production by Klebsiella oxytoca
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 114, 15 October 2016, Pages 94–100
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us