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Photophysical properties and interactions of xanthene dyes in aqueous micelles

Paper ID Volume ID Publish Year Pages File Format Full-Text
26798 43979 2012 8 PDF Available
Title
Photophysical properties and interactions of xanthene dyes in aqueous micelles
Abstract

Photosensitizers (PS) photodynamic activities are regulated by their location in the biological target, which modulates their photophysical and photochemical features. In this work the PS partition for the Xanthene Dyes Fluorescein (FSC), Eosin Y (EOS), Erythrosin B (ERY) and Rose Bengal B (RBB) in biomimetic models (SDS, CTAB and Pluronic P-123 micelles) and the effects on their photophysical characteristics are evaluated. The hydrophobic and electrostatic forces that govern the PS–micelle interaction are analyzed. At physiological pH (7.25), the ability of the dianionic protolytic form of the dyes to be positioned into the micelle palisade and its micelle interaction depends not only on the hydrophobicity of the dye but also on the micellar surface charge. The Binding Constants obey exactly the same order of the Partition Coefficients for the dyes in P-123 and CTAB micelles. The Stern–Volmer treatment pointed out that dyes are located inside the micelle, especially ERY and RBB. The magnitude of the dye–micelle interaction increased from SDS, P-123 and finally CTAB micelles due to the charges between dye and micelle, and among the xanthenes, their hydrophobic characteristics. Within the micelle pseudo phase, ERY and RBB are still very efficient photosensitizers exhibiting high quantum yield of singlet oxygen, which turns them very attractive especially with P-123 polymeric system as drug delivery systems in photodynamic therapy.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► We evaluated the influence of the hydrophilic–lipophilic balance on the interaction between xanthenes dyes and micellar systems. ► Physicochemical and photophysical properties of these dyes and micellar medium have been studied. ► Erythrosin and Rose Bengal B have shown very interesting properties to be applied in PDT and PDIMO.

Keywords
Xanthenes; Micelles; Polymeric micelles; Binding constants; Photodynamic therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 247, 1 November 2012, Pages 8–15
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us