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Elimination of an anticancer drug (cyclophosphamide) by a membrane bioreactor: Comprehensive study of mechanisms

Paper ID Volume ID Publish Year Pages File Format Full-Text
2685 126 2016 9 PDF Available
Title
Elimination of an anticancer drug (cyclophosphamide) by a membrane bioreactor: Comprehensive study of mechanisms
Abstract

•Membrane bioreactor showed a high removal efficiency (60%) of cyclophosphamide.•Sorption onto sludge could be neglected.•Biodegradation was the predominant removal mechanism.•Co-metabolic biodegradation linked to nitrogen elimination was assumed.

The mechanisms of elimination of an anticancer drug (cyclophosphamide) by a membrane bioreactor were investigated. The membrane bioreactor was run for 153 days with a sludge retention time (SRT) of 20 days. A removal efficiency of 60% was observed despite some variations in the influent. This removal was higher than reported in most of the studies in the literature. Biodegradation was the predominant removal mechanism and sorption onto sludge could be neglected.

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Keywords
Membrane bioreactor (MBR); Wastewater treatment; Pharmaceuticals; Cyclophosphamide; Biodegradation rate; Sorption
First Page Preview
Elimination of an anticancer drug (cyclophosphamide) by a membrane bioreactor: Comprehensive study of mechanisms
Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 114, 15 October 2016, Pages 155–163
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering