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Inactivation of clinically relevant pathogens by photocatalytic coatings

Paper ID Volume ID Publish Year Pages File Format Full-Text
26854 43981 2010 8 PDF Available
Title
Inactivation of clinically relevant pathogens by photocatalytic coatings
Abstract

Novel disinfection methods are being sought to provide additional means of protection in a number of areas where disease outbreaks could lead to illness or fatalities. For example, the risk of contamination arising from contact with surfaces and medical devices has received much attention due to the rise in incidence of healthcare acquired infections. It is possible that reducing bio-burden on these sites may supplement the disinfection protocols currently in place and help reduce risk of infection. Photocatalytic surfaces offer promise as innovative and cost-effective biocidal engineering solutions which address these specific problems whilst maintaining stringent health and safety controls.A method was developed to assess the disinfection efficiency of photocatalytic surfaces allowing (a) determination of pathogen viability as a function of treatment time; (b) assessment of the surface for viable surface bound organisms following disinfection; (c) measurement of the re-growth potential of inactivated organisms. This method was used to demonstrate the inactivation of extended-spectrum beta-lactamase Escherichia coli, methicillin resistant Staphylococcus aureus, Pseudomonas aeruginosa and Clostridium difficile spores using immobilised films of commercial titania nanoparticles. 99.9% reduction in viability (a 3-log kill) was observed for all bacterial cells within 80 min photocatalytic treatment. Complete surface inactivation was demonstrated and bacterial re-growth following photocatalytic treatment was not observed. Greater than 99% inactivation (2.6-log reduction) was observed when the photocatalytic surfaces were challenged with C. difficile spores.The efficacy of photocatalytic disinfection to inactivate Staphyloccocus epidermidis cells within a biofilm was also demonstrated, with 3 h treatment rendering 96.5% ± 6 of the biofilm cells on the TiO2 coated substrate non-viable. Disinfection of cells throughout the 3–4 μm thick biofilm was observed.

Keywords
Photocatalysis; Titanium dioxide; Disinfection; Healthcare acquired infection; Clostridium difficile; Biofilm
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Inactivation of clinically relevant pathogens by photocatalytic coatings
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 216, Issues 2–3, 15 December 2010, Pages 303–310
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us