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Photodegradation of flupentixol in aqueous solution under irradiation at 254 nm: Identification of the photoproducts generated

Paper ID Volume ID Publish Year Pages File Format Full-Text
26911 43986 2010 6 PDF Available
Title
Photodegradation of flupentixol in aqueous solution under irradiation at 254 nm: Identification of the photoproducts generated
Abstract

After irradiation at 254 nm of aqueous solutions of the antipsychotic drug flupentixol, the structures of the photodegradation products were determined by ultra high performance liquid-chromatography linked to mass spectrometry. Fragmentation patterns of the parent ions were established on a hybrid linear ion trap–orbitrap mass spectrometer allowing accurate mass measurements of both parent and daughter ions. This allowed to propose plausible structures for the main photolysis products of flupentixol. A total of nine photoproducts were detected after irradiation of the drug. The main photoproduct is generated following the addition of a hydroxyl group on the double bond adjacent to the thioxanthene ring. Secondary photoproducts were also observed.

Keywords
Flupentixol; Photolysis products; UHPLC; Mass spectrometry; MSn
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Photodegradation of flupentixol in aqueous solution under irradiation at 254 nm: Identification of the photoproducts generated
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 214, Issues 2–3, 15 August 2010, Pages 224–229
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
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