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UVA generated free radicals in irinotecan (CPT-11) in the presence of copper ions

Paper ID Volume ID Publish Year Pages File Format Full-Text
26948 43988 2014 14 PDF Available
Title
UVA generated free radicals in irinotecan (CPT-11) in the presence of copper ions
Abstract

Irinotecan (CPT-11) is an efficient anticancer drug approved for clinical use in the treatment of advanced colorectal cancers. This work is focused on the study of photoinduced processes in irinotecan (CPT-11) both in the presence and absence of Cu(II) ions by means of UV/vis and EPR spectroscopy. Solid-state EPR revealed the solvent dependent coordination between CPT-11 and cupric ions. EPR spin trapping technique, using various spin trapping agents, was applied to monitor the generation of reactive radical species (oxygen- and carbon-centered radicals) in irradiated CPT-11 and CPT-11/CuCl2 systems under the given experimental conditions. We confirmed that the presence of CPT-11 is necessary for the formation of reactive radicals and the photoinduced processes are influenced by the presence of cupric ions. ROS generated upon irradiation of CPT-11 in the presence/absence of copper ions can be regarded as complementary species to the original inhibitory action of the drug on the DNA topoisomerase I.

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Keywords
ACN, acetonitrile; CPT, camptothecin; CPT-11, irinotecan; DIPPMPO, 5-(diisopropoxy-phosphoryl)-5-methyl-1-pyrroline N-oxide; DPPH, 2,2-diphenyl-1-picrylhydrazyl; DMPO, 5,5-dimethyl-1-pyrroline N-oxide; DMSO, dimethylsulfoxide; DNA, deoxyribonucleic acid;
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UVA generated free radicals in irinotecan (CPT-11) in the presence of copper ions
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 290, 15 September 2014, Pages 125–138
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us