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Synthesis and G-quadruplex binding study of a novel full visible absorbing perylene diimide dye

Paper ID Volume ID Publish Year Pages File Format Full-Text
26996 43992 2012 9 PDF Available
Title
Synthesis and G-quadruplex binding study of a novel full visible absorbing perylene diimide dye
Abstract

A novel perylene diimide dye containing glucopyranosyl groups in 1- and 7-positions of the perylene ring has been synthesized and characterized to obtain highly efficient and stable photosensitized material in photodynamic therapy. Solvatochromic studies on this dye in solvents of different polarities have indicated that absorption bands of the dye cover the whole visible spectrum in more polar organic solvents. It shows absorption bands localized at 350–500 nm and 600–850 nm in benzonitrile giving a green color. Also, the dye has a wide absorption region which covers the wavelength between 400 and 800 nm in more polar solvents by changing the dye concentration in the solvents. Singlet oxygen generation efficiency and G-quadruplex binding affinity of the dye have been tested. Theoretical calculations through semi-empirical methods have been performed and a detailed spectroscopic assignment of the molecule has been also presented.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Absorptions of the dye cover the whole visible spectrum in polar organic solvents. ► The dye PDI-Ph-β-GluOAc is good candidate for PDT because of its good singlet O2 generation capacity. ► G-quadruplex binding affinity of the dye may have utility in PDT applications. ► The dye binding to G-quadruplex is suitable for targeted PDT strategy.

Keywords
Perylene diimide; Solvatochromism; Charge transfer; Singlet oxygen; G-quadruplex
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Synthesis and G-quadruplex binding study of a novel full visible absorbing perylene diimide dye
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 235, 1 May 2012, Pages 40–48
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us