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Actinobacillus succinogenes: Advances on succinic acid production and prospects for development of integrated biorefineries

Paper ID Volume ID Publish Year Pages File Format Full-Text
2700 127 2016 19 PDF Available
Title
Actinobacillus succinogenes: Advances on succinic acid production and prospects for development of integrated biorefineries
Abstract

•Evaluation of Actinobacillus succinogenes as an established succinic acid producer.•Focus on the importance of by-product formation during fermentation.•The metabolism of A. succinogenes is discussed extensively.•The prospect of integrating succinic acid production in future biorefineries is assessed.

Actinobacillus succinogenes is a wild-type bacterial strain, isolated from bovine rumen, known as one of the most efficient natural producers of succinic acid. Herein, the factors contributing to the fermentative production of succinic acid by A. succinogenes are reviewed with particular focus on raw materials, culture conditions, significance of carbon dioxide availability and downstream separation and purification. The metabolic potential of this strain is evaluated through discussion of the pathways involved in succinic acid production, genome analysis as well as the development of A. succinogenes mutants. The review also addresses the importance of by-product formation during fermentation that constitutes an important aspect regulating succinic acid production by A. succinogenes. The prospect of integrating succinic acid production in future biorefineries is assessed.

Keywords
Actinobacillus succinogenes; Bioconversion; Product inhibition; Downstream processing; Integrated biorefineries; Renewable resources
First Page Preview
Actinobacillus succinogenes: Advances on succinic acid production and prospects for development of integrated biorefineries
Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 112, 15 August 2016, Pages 285–303
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering