fulltext.study @t Gmail

Phototransformation of the drug rivastigmine: Photoinduced cleavage of benzyl-nitrogen sigma bond

Paper ID Volume ID Publish Year Pages File Format Full-Text
27123 44003 2012 6 PDF Available
Title
Phototransformation of the drug rivastigmine: Photoinduced cleavage of benzyl-nitrogen sigma bond
Abstract

The photochemical behaviour of rivastigmine has been investigated under UV-B irradiation by HPLC and NMR. Kinetic data have been obtained irradiating aqueous solutions (5 × 10−5 M). For mechanistic purposes and products studies irradiation has also been carried out on concentrated solutions (1 × 10−3 M) in water/acetonitrile, acetonitrile, methanol, methanol/acetonitrile, in the presence and absence of oxygen. Photoproducts, isolated by chromatographic processes, have been identified by spectroscopic means. Photochemical cleavage of the benzyl-nitrogen bond occurs and leads to radical-derived and, mainly, ion-derived products. Mechanistic pathways have been hypothesised on the basis of both steady-state irradiation and laser flash photolysis experiments.

► By UV-B radical and/or ionic cleavage of the benzyl amine group of the drug occurs. ► Mechanistic routes are based on steady-state and laser flash photolysis experiments. ► Water as solvent plays a determinant role in favouring electron-transfer reactions. ► The main photoproduct, an aryl ketone, is a photosensitizer.

Keywords
Drug; Benzylic amines; Photooxidation; Electron transfer; Laser flash photolysis
First Page Preview
Phototransformation of the drug rivastigmine: Photoinduced cleavage of benzyl-nitrogen sigma bond
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 239, 1 July 2012, Pages 1–6
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us