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Photochemistry of a novel antimuscarinic drug fesoterodine and identification of its photodegradation products by LC–ESI–MS studies

Paper ID Volume ID Publish Year Pages File Format Full-Text
27170 44006 2013 7 PDF Available
Title
Photochemistry of a novel antimuscarinic drug fesoterodine and identification of its photodegradation products by LC–ESI–MS studies
Abstract

Fesoterodine (FESO) is a novel muscarinic receptor antagonist for the treatment of overactive bladder syndrome. The aim of this work was to study the photodegradation of FESO, to determine its kinetics and to identify the photodegradation products. The photochemistry of FESO was investigated in sample solutions exposed to a UV-A (320–400 nm) and UV-C irradiation (100–280 nm) at room temperature. The photodegradation process was monitored by means of liquid chromatography method equipped with monolithic column and photodiode array detector. This drug is more photolabile under UV-C light. In methanol–water solution (1:1, v/v), approximately 62.5% of FESO decomposes after 60 min of UV-C irradiation, whereas under 6 h of UV-A light only 4.9% decomposes. FESO was shown to be photolabile and its photodegradation reaction followed the zero-order kinetics with the rate constant k = 0.5503 min−1, and t1/2 and t90% obtained were 46.92 min and 9.38 min, respectively. The main degradation products were isolated by semi-preparative liquid chromatography and identified by liquid chromatography coupled to an electrospray ionization mass spectrometry. The powdered and intact tablets were also exposed to UV-C irradiation. Based on the obtained results, a complete drug photodegradation pathway was proposed.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Photodegradation process was monitored by LC with monolithic column and PDA detection. ► Photodegradation reaction of fesoterodine followed the zero-order kinetics. ► Degradation products were isolated by semi-preparative LC method. ► Four new degradation products were identified by LC–ESI–MS method. ► Complete drug photodegradation pathway was proposed.

Keywords
Fesoterodine; Photochemistry; Isolation and identification; Degradation products; LC–ESI–MS studies
First Page Preview
Photochemistry of a novel antimuscarinic drug fesoterodine and identification of its photodegradation products by LC–ESI–MS studies
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 256, 15 March 2013, Pages 16–22
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering