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Competitive processes of a chromophore modified α-cyclodextrin in the presence of a fluorescence polarity sensitive probe

Paper ID Volume ID Publish Year Pages File Format Full-Text
27174 44006 2013 10 PDF Available
Title
Competitive processes of a chromophore modified α-cyclodextrin in the presence of a fluorescence polarity sensitive probe
Abstract

Steady-state fluorescence, time-resolved fluorescence, molecular mechanics (MM) and molecular dynamics (MD) were employed to study the thermodynamics of the complexation of 2I, 3I-O-(o-xylylene)-α-cyclodextrin (XαCD), which is also capable of self-aggregation, with a fluorescent polarity sensitive probe, the 2-naphthalenecarboxylate (2MN), in aqueous solution. Dimerization and inclusion constants, as well as the thermodynamics parameters accompanying both processes were obtained. We also used MM and MD to investigate the conformational behavior for the isolated XαCD, the dimerization and inclusion processes and the geometry of the complexes and driving forces responsible for their formation. The results were compared with those obtained for other α-cyclodextrins in order to establish relationships between the dimer and complex structures and the thermodynamics of both processes.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Xylylene-α-cyclodextrin in presence of a fluorescence probe shows both dimerization and inclusion competitive processes. ► Thermodynamics parameters accompanying both processes were obtained. ► Structure and forces responsible for self-aggregation and complexation were investigated.

Keywords
Modified cyclodextrin; Fluorescence; Molecular modeling; Host–guest complexation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 256, 15 March 2013, Pages 42–51
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Price was $35.95
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Price after discount Only $4.95
100% Money Back Guarantee
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