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Automatic multiple photodegradation unit on a multipumping flow system: Monitoring of ketoprofen

Paper ID Volume ID Publish Year Pages File Format Full-Text
27284 44014 2013 8 PDF Available
Title
Automatic multiple photodegradation unit on a multipumping flow system: Monitoring of ketoprofen
Abstract

•Implementation of a multiple photodegradation unit in an automatic flow system.•Irradiation with UV light of up to 5 samples simultaneously.•Independent control of the 5 samples inserted into the automatic system.•Time for analytical optimizations and analysis improved up to 5 times.•Development of an analytical methodology for the determination of ketoprofen.

The main objective of this work was the development of a clean methodology involving the use of the multipumping flow concept for the determination of ketoprofen, a non-steroidal anti-inflammatory drug (NSAID), in pharmaceutical samples, thus providing the pharmaceutical industry with an environmental friendly, rapid and low cost method for the chemical control of commercial formulations and an expeditious alternative to the commonly used chromatographic methods.The core element of the proposed work is the implementation of a multiple photodegradation unit that was applied to ketoprofen monitoring through fluorometric detection (λex = 330 nm; λem = 401 nm) of the photodegradation product obtained upon UV irradiation. The photodegradation was performed in a methanol/nitric acid medium, being these the only reagents used in the method. A linear working response range for ketoprofen concentrations of up to 50 mg L−1 was obtained, with a correlation coefficient of 0.9997. The detection limit was about 1.45 mg L−1. The results obtained for the determination of ketoprofen in commercial pharmaceutical formulations by the proposed flow procedure, when compared to those furnished by the HPLC reference procedure revealed a good agreement, with relative deviations comprised between −3.1 and 2.2%.

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Keywords
Photodegradation; Fluorescence; Ketoprofen; Multipumping; NSAID; Automatic
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Automatic multiple photodegradation unit on a multipumping flow system: Monitoring of ketoprofen
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 271, 1 November 2013, Pages 77–84
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us