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Photochemical activity of glenvastatin, a HMG-CoA reductase inhibitor

Paper ID Volume ID Publish Year Pages File Format Full-Text
27319 44016 2011 7 PDF Available
Title
Photochemical activity of glenvastatin, a HMG-CoA reductase inhibitor
Abstract

Photochemical properties of glenvastatin (HR 780), a HMG-CoA reductase inhibitor, were studied. The drug was exposed to light in liquid state under aerobic conditions. The source of irradiation was an HBO-50 lamp. The lamp was equipped with a mercury burner and an appropriate set of glass filters. The conditions during photodegradation were the same as specified in the first version of the ICH Document.Photoproducts formed after illumination of a methanol solution of glenvastatin were identified by several analytical techniques, including: spectrophotometry, HPLC and HPLC–MS. Quantitative evaluation of photochemical degradation of glenvastatin was made on the basis of UV–Vis spectrophotometric and HPLC. The irradiation photodecomposition of glenvastatin led preferentially to two main photoproducts being stereoisomers. The photoproducts were isolated with the help of a semipreparative HPLC method and identified by mass spectrometry. As a result of glenvastatin exposure to irradiation, the heptene chain is oxidised and its cyclisation takes place with formation of two diastereoisomers containing three condensed rings.

Graphical abstractGlenvastatin exposure to irradiation, the heptene chain is oxidised and its cyclisation takes place with formation of two diastereoisomers containing three condensed rings.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Glenvastatin – a HMG-CoA reductase inhibitor – is very sensitivity to light. ► Photoproducts were identified by spectrophotometry, HPLC and HPLC–MS. ► The products of photochemical decomposition of glenvastatin are diastereoisomers.

Keywords
Statins; Photostability; Photodegradation; Light; Stability; Drugs
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 224, Issue 1, 15 November 2011, Pages 1–7
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us