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Characterization of transient species produced from laser flash photolysis of a new cardioprotective drug: S-propargyl-cysteine

Paper ID Volume ID Publish Year Pages File Format Full-Text
27458 44024 2011 5 PDF Available
Title
Characterization of transient species produced from laser flash photolysis of a new cardioprotective drug: S-propargyl-cysteine
Abstract

S-propargyl-cysteine (SPRC), a sulfur-containing amino acid, was proved to have cardioprotective effect mediated by the CSE/H2S pathway. In this study, photo-ionization of SPRC was investigated by 266 nm laser flash photolysis. Irradiated by 266 nm laser pulse, SPRC in aqueous solution experienced photo-ionization via a bi-photon process to produce hydrated electron, anion radical (SPRC−), and neutral radical (SPRC(–H)). The reaction of SPRC with SPRC− was found and the pKa of SPRC+ was determined. Oxidation of SPRC by SO4− not only confirmed the assignment of SPRC(–H), but also provided an evidence for the antioxidant activity of SPRC.

► Photo-ionization of S-propargyl-cysteine (SPRC), a new cardioprotective drug, was investigated by 266 nm laser flash photolysis. Irradiated by 266 nm laser pulse, SPRC in aqueous solution experienced photo-ionization via a bi-photon process to produce hydrated electron, anion radical (SPRC−), and neutral radical (SPRC(–H)). The reaction of SPRC with SPRC− was found and the pKa of SPRC+ was determined. Oxidation of SPRC by SO4−confirmed the assignment of SPRC(–H) and provided an evidence for the antioxidant activity of SPRC.

Keywords
Laser flash photolysis; S-propargyl-cysteine; Cardioprotective drug; Sulfur-containing amino acid; Antioxidant
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Characterization of transient species produced from laser flash photolysis of a new cardioprotective drug: S-propargyl-cysteine
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 219, Issues 2–3, 15 April 2011, Pages 195–199
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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