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Design and evaluation of chitosan-β-cyclodextrin based thermosensitive hydrogel

Paper ID Volume ID Publish Year Pages File Format Full-Text
2766 130 2016 8 PDF Available
Title
Design and evaluation of chitosan-β-cyclodextrin based thermosensitive hydrogel
Abstract

•The hydrogel was prepared with chitosan, β-cyclodextrin and αβ-glycerol phosphate.•The thermosensitivity, SEM, FT/IR and release efficiency of the hydrogel were studied.•The hydrogel had good sustained releases efficiency on the hydrophobic drug.•CS-β-CD hydrogel and CS-β-CD-In hydrogel were best fit with Peppas model.

The thermosensitive hydrogel was prepared by embedding β-cyclodextrin into chitosan/αβ-glycerol phosphate system. The optimal parameters were that the ratio of CS/β-CD was 2/1 (w/w) and the ratio of CS-β-CD/αβ-GP was 9.0/1.0 (v/v), where the gelation time was less than 3 min. The hydrogels had obvious lamellar structure, self-comparability, fractal characteristic and had good sustained release efficiency on the hydrophobic drug. Furthermore, the release rate of CS-β-CD-In hydrogel was slower than that of CS-β-CD hydrogel which indicated that the model drug (Asprin), added as Asp-β-CD inclusion, was beneficial for sustaining the release from the modified hydrogel system. The analysis of release kinetics indicated that both CS-β-CD based hydrogel and CS-β-CD-In hydrogel showed best fit with Peppas model and had potential as sustained release drug delivery system.

Keywords
Chitosan; β-Cyclodextrin; Inclusion; Thermosensitive hydrogel; in vitro release; Release kinetics
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Design and evaluation of chitosan-β-cyclodextrin based thermosensitive hydrogel
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 111, 15 July 2016, Pages 100–107
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us