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Complexation of Mg-tetrabenzoporphyrin with pyridine enhances singlet oxygen generation and affects its partitioning into apolar microenvironments

Paper ID Volume ID Publish Year Pages File Format Full-Text
27844 44046 2009 6 PDF Available
Title
Complexation of Mg-tetrabenzoporphyrin with pyridine enhances singlet oxygen generation and affects its partitioning into apolar microenvironments
Abstract

Photophysical and singlet oxygen (1O2) sensitization processes of Mg-tetrabenzoporphyrin (MgTBP) were studied upon complexation of the central Mg ion with pyridine. The addition of pyridine affected the absorption spectrum of MgTBP due to complexation, shifting the Soret absorption peak by as much as 13 nm. Principal component analysis (PCA) was employed to resolve the spectrum of MgTBP from the mono-ligand and bi-ligand complexes, MgTBP(pyr)1 and MgTBP(pyr)2, respectively. We found that the quantum yield of singlet oxygen production (ΦΔ) by MgTBP was also affected by complexation of pyridine. In chloroform, toluene, water and SDS micelles the bi-ligand complexes had a higher quantum yield than MgTBP, by as much as 70%. In those solvents in which the mono-liganded complex was isolated, we found that its singlet oxygen quantum yield was higher than that of MgTBP by up to 20%. This enhancement can be explained by a relatively more efficient intersystem crossing of the complexes. We also found that MgTBP is capable of intercalating into a non-polar microenvironment of SDS micelles or lecithin liposomes. The axial pyridine ligands were, however, shed-off when the molecule entered the lipid bilayer of liposomes while they remained complexed when entering the micelle environment. This probably arises from the tight and ordered liposomal lipid phase as compared with the more fluid micellar environment.

Keywords
Complexation; Ligand; Liposomes; Micelles; Photosensitization; Principal component analysis; Pyridine
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Complexation of Mg-tetrabenzoporphyrin with pyridine enhances singlet oxygen generation and affects its partitioning into apolar microenvironments
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 203, Issue 1, 5 March 2009, Pages 7–12
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us