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Characterization of mixed DODAB/monoolein aggregates using Nile Red as a solvatochromic and anisotropy fluorescent probe

Paper ID Volume ID Publish Year Pages File Format Full-Text
27848 44046 2009 8 PDF Available
Title
Characterization of mixed DODAB/monoolein aggregates using Nile Red as a solvatochromic and anisotropy fluorescent probe
Abstract

The aim of this study was to get a further knowledge of the interactions between lamellar and non-lamellar forming-phospholipids, as a tool to better understand the membrane dynamics and function. We have studied the behavior of aqueous mixtures of a cationic lipid (dioctadecyldimethylammonium bromide) and a neutral phospholipid (1-monoolein) in 10–150 μM total lipid concentration range. The effect of 1-monoolein on the physical properties (microviscosity, hydration and polarity) of the self-organized mixed aggregates was accessed by studying the steady-state fluorescence emission and anisotropy of the dye Nile Red. This information was combined with 90° Static Light Scattering assays in order to detect any structural variations in these vesicle systems. The results were interpreted by the coexistence of vesicular structures and other aggregates probably with a bicontinuous nature.

Keywords
DODAB; Monoolein; Nile Red; Polarity; Hydration
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Characterization of mixed DODAB/monoolein aggregates using Nile Red as a solvatochromic and anisotropy fluorescent probe
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 203, Issue 1, 5 March 2009, Pages 32–39
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us