fulltext.study @t Gmail

Photolability of potential calcium channel antagonists: Hexahydroquinoline derivatives

Paper ID Volume ID Publish Year Pages File Format Full-Text
27888 44048 2007 7 PDF Available
Title
Photolability of potential calcium channel antagonists: Hexahydroquinoline derivatives
Abstract

Photodegradation of three chlorinated derivatives—Compound I (2′-chloro-), Compound II (3′-chloro-) and Compound III (2′,3′-dichloro-) of methyl 2,6,6-trimethyl-4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate was studied in the conditions recommended by the International Conference on Harmonization (ICH) in the liquid phase. Photodegradation kinetics of the three compounds in methanolic solutions was studied by means of the spectrophotometric method. Reactions followed the first-order kinetic equation. The measured real quantum yields of photodegradation were 1.2 × 10−4, 4.0 × 10−5 and 3.0 × 10−5, respectively. Gas chromatography–mass spectrometry (GC–MS) was used to identify the photodegradation products, with the main products formed by oxidation of the dihydropyridine ring to pyridine derivatives. Mass fragmentation pathways of the photoproducts were also described.

Keywords
Calcium channel blockers; Photostability; Drugs; Photodegradation; Dihydropyridine derivatives
First Page Preview
Photolability of potential calcium channel antagonists: Hexahydroquinoline derivatives
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 192, Issues 2–3, 15 December 2007, Pages 197–203
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us