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Biological production of adipic acid from renewable substrates: Current and future methods

Paper ID Volume ID Publish Year Pages File Format Full-Text
2799 136 2016 11 PDF Available
Title
Biological production of adipic acid from renewable substrates: Current and future methods
Abstract

•Adipic acid is an important chemical with a multiple billion dollar market.•Biological synthesis of precursors for adipic acid production.•Direct synthesis of adipic acid from renewable substrates biologically.•Strategies for increasing the yield of adipic acid from renewable substrates.•We review the current methods and perspectives of biological adipic acid synthesis.

Adipic acid has been widely used for producing thermoplastic polyurethane resins, nylon 6-6, adhesives, synthetic lubricants and plasticizers, and the global market for adipic acid is estimated at approximate $6.3 billion per year. Currently, 2.85 million tons of adipic acid are produced from petrochemical sources, mostly by oxidation of KA oil (cyclohexanol and cyclohexanone) catalyzed by nitric acid. The chemical synthesis of adipic acid is of serious consequences such as greenhouse gases and heavy pollution to the environment, etc. The researchers are struggling to establish more reliable, renewable and affordable adipic acid synthesis methods, and among which, biological synthesis of adipic acid is attracting the most attention. There are two biological routes for adipate synthesis: (1) biological accumulations of precursors of adipic acid such as d-glucaric acid and cis,cis-muconic acid, which can be further catalyzed to adipate; (2) synthesis of adipate directly from carbon source. With the emergence of metabolic engineering and synthetic biology, biological synthesis of adipic acid from renewable substrates is now feasible. Here, we review the new approaches and technologies to produce adipic acid biologically, with the direct synthesis of adipic acid from the renewable substrates of special interest.

Keywords
Adipic acid; Metabolite over production; Biosynthesis; Consolidated bioprocessing (CBP); Biocatalysis; Fermentation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 105, Part A, 15 January 2016, Pages 16–26
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us