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Efficient photocleavage of DNA utilizing water soluble riboflavin/naphthaleneacetate substituted fullerene complex

Paper ID Volume ID Publish Year Pages File Format Full-Text
28112 44060 2009 7 PDF Available
Title
Efficient photocleavage of DNA utilizing water soluble riboflavin/naphthaleneacetate substituted fullerene complex
Abstract

Riboflavin (RF), a metabolizable endogenous pigment, can significantly enhance the water solubility of naphthaleneacetate modified fullerene C60 (NP-C60) upon formation of a supramolecular complex (RF/NP-C60). NP-C60 can quench the fluorescence of RF efficiently through static quenching mechanism. The resulting complex exhibits strong affinity to calf thymus DNA, as indicated by the hypochromism of its absorption spectra. Under anaerobic conditions, RF/NP-C60 complex displays much more efficient photocleavage of the DNA than RF itself due to the occurrence of electron transfer from DNA to NP-C60.

Keywords
Fullerene; DNA cleavage; Riboflavin; Supramolecular complex; Photoinduced electron transfer
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Efficient photocleavage of DNA utilizing water soluble riboflavin/naphthaleneacetate substituted fullerene complex
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 203, Issues 2–3, 15 April 2009, Pages 105–111
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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