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Polycyclic compounds by sunlight exposure of the drug rosuvastatin in water

Paper ID Volume ID Publish Year Pages File Format Full-Text
28235 44066 2007 6 PDF Available
Title
Polycyclic compounds by sunlight exposure of the drug rosuvastatin in water
Abstract

Irradiation of rosuvastatin in water by sunlight or UV lamp (Pyrex) affords cyclic compounds. The main photo-induced reaction is cyclization of the drug to give diastereomeric dihydrobenzoquinazolines. Products derived from side-chain loss were also isolated in the irradiation mixture, and characterized as dihydrobenzoquinazoline and benzoquinazoline derivatives by spectroscopic means. Photoproducts structure elucidation and mechanistic hypothesis are reported.

Keywords
Rosuvastatin; Dihydrobenzoquinazolines; Benzoquinazolines; Photocyclization; Photoxidation
First Page Preview
Polycyclic compounds by sunlight exposure of the drug rosuvastatin in water
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 187, Issues 2–3, 15 April 2007, Pages 263–268
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering