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Mechano growth factor-C24E, a potential promoting biochemical factor for ligament tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
2826 136 2016 15 PDF Available
Title
Mechano growth factor-C24E, a potential promoting biochemical factor for ligament tissue engineering
Abstract

•MGF-C24E inhibits static stretch induced ER-stress.•MGF-C24E induces LOXs family genes expression.•MGF-C24E regulates stretch induced cell deformation.•MGF-C24E regulates viscoelasticity of cells.

Ligaments play an important role in stabilizing and balancing knee joint movement. Anterior cruciate ligament (ACL) injuries remain a challenge in clinical and experimental settings due to the poor healing potential of ACL injuries. This study investigates whether the short peptide Mechano growth factor-C24E (MGF-C24E) is an efficient biochemical factor to promote repair of ACL injuries. We found that MGF-C24E-treated (5–30 ng/ml) synovial fibroblasts (SFs) subjected to the static stretching (12% strain) were experienced significant lower oxidative stress, endoplasmic reticulum stress, and the activity of matrix metalloproteinases (MMPs) by SFs was also decreased. In addition, when ACL fibroblasts (ACLFs) were injured and then cultured in SFs culture medium after the SFs had been treated with MGF-C24E, the ACLFs exhibited increased proliferation, migration, collagen synthesis and enhanced mechanical recovery. These results indicate that MGF-C24E can interact with injured SFs and affect the injury microenvironment of the knee to promote ACLFs mechanical injury repair.

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Keywords
Ligament tissue engineering; Mechano growth factor; Biomedical; Polypeptides; Tissue cell culture; Physiology
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Mechano growth factor-C24E, a potential promoting biochemical factor for ligament tissue engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 105, Part A, 15 January 2016, Pages 249–263
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us